You come from the Highway: A7 departure Kassel-Nord,- A 49 departure Kassel-Auestadion,- A 44 departure Südkreuz Kassel and take A 49 departure Kassel-Auestadion. After that you take direction to Kassel Stadtmitte and take the Innenstadtring and follow the signs Haupt- und Kulturbahnhof. On Werner-Hilpert-Straße between Hotel Excelsior and Haupt- und Kulturbahnhof you turn into the Erzbergerstraße and you will see your destination.
Or you follow the hotelroute (green signs) with Domus.