From main station:
Go straight ahead towards the Kaiserstraße and take the first street on the left onto the Moselstraße.
From fairgrounds:
Take the Theodor-Heuss-Allee until the main station, then turn left onto the Kaiserstraße and take the first street left onto the Moselstraße.
From airport:
S8 or S1 towards city centre (approximately 20 minutes), exit at the main station then as above.
From motorway:
Towards Frankfurter Kreuz, then A648 towards city centre, then Theodor-Heuss-Allee towards main station.